Differential regulation of phospholipase D and phospholipase A2 by protein kinase C in P388D1 macrophages
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چکیده
منابع مشابه
Regulation of cytosolic phospholipase A2 by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages
In resident mouse peritoneal macrophages, group IVA cytosolic phospholipase A2 (cPLA2 ) mediates arachidonic acid (AA) release and eicosanoid production in response to diverse agonists such as A23187, phorbol myristate acetate, zymosan, and the enterotoxin, okadaic acid (OA). cPLA2 is regulated by phosphorylation and by calcium that binds to the C2 domain and induces translocation from the cyto...
متن کاملRegulation of phospholipase D2 activity by protein kinase C alpha.
It has been well documented that protein kinase C (PKC) plays an important role in regulation of phospholipase D (PLD) activity. Although PKC regulation of PLD1 activity has been studied extensively, the role of PKC in PLD2 regulation remains to be established. In the present study it was demonstrated that phorbol 12-myristate 13-acetate (PMA) induced PLD2 activation in COS-7 cells. PLD2 was al...
متن کاملRegulation of Phospholipase D2 Activity by Protein Kinase C *
It has been well documented that protein kinase C (PKC) plays an important role in regulation of phospholipase D (PLD) activity. Although PKC regulation of PLD1 activity has been studied extensively, the role of PKC in PLD2 regulation remains to be established. In the present study it was demonstrated that phorbol 12myristate 13-acetate (PMA) induced PLD2 activation in COS-7 cells. PLD2 was als...
متن کاملInhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages.
Cellular levels of free arachidonic acid (AA) are controlled by a deacylation/reacylation cycle whereby the fatty acid is liberated by phospholipases and reincorporated by acyltransferases. We have found that the esterification of AA into membrane phospholipids is a Ca(2+)-independent process and that it is blocked up to 60-70% by a bromoenollactone (BEL) that is a selective inhibitor of a newl...
متن کاملRole of protein kinase C in the regulation of phospholipase A2 activity in human platelets.
involved in receptor-phospholipase C coupling. Hence. the effect o f GTPlS] may result from an action at a guanine nucleotide-binding protein (GI ) acting closer t o the exocytotic site, as suggested in other systems, e.g. ,4glucuronidasc secretion from neutrophils 15 I and histamine secretion from mast cells 161. For amine storage granule secretion, such B GTPlSl action cannot be distal t o C ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1997
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3210805